Abstract
A series of N-substituted analogs based upon the spiropiperidine core of 1 was synthesized and exhibited high binding affinity to the nociceptin (NOP) receptor. The selectivities against other known opioid receptors were determined.
MeSH terms
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Administration, Oral
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Animals
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Cough / drug therapy
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Drug Evaluation, Preclinical
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Guanosine 5'-O-(3-Thiotriphosphate)
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Ligands
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Nociceptin Receptor
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Pharmacokinetics
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Piperidines / chemical synthesis*
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Piperidines / pharmacokinetics
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Piperidines / pharmacology
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Protein Binding
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Rats
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Receptors, Opioid / agonists*
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Receptors, Opioid / metabolism
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Spiro Compounds / chemical synthesis
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Spiro Compounds / pharmacokinetics
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Spiro Compounds / pharmacology
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Structure-Activity Relationship
Substances
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Ligands
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Piperidines
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Receptors, Opioid
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Spiro Compounds
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Guanosine 5'-O-(3-Thiotriphosphate)
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Nociceptin Receptor
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Oprl protein, rat